Christian McCaffrey

Start Christian McCaffrey — with the 49ers missing key pass-catchers he should touch the ball 20–30+ times and catch plenty of passes, so he’s a safe play. He had a minor calf issue but is listed active; only sit him if he’s officially ruled out before kickoff.

Start Christian McCaffrey if he plays — he usually piles up yards and touchdowns against Seattle and will get a lot of touches. He’s dealing with a calf issue, so check his game-day status; if he can’t go, plug in Brian Robinson Jr. instead.

Yes — take him in the late first or early second round if you want a player who can carry your team when healthy, but remember he's 29 and has a history of leg injuries. Experts disagree, so only pick him if you’re okay with the risk and also grab his backup in case he misses time.

You probably shouldn't pick McCaffrey early. He's had a lot of work and is getting older, which makes him more likely to get hurt or not perform as well next season. You could consider him if he falls to a later pick, but the risk is pretty high right now.