Christian McCaffrey

Start Christian McCaffrey — he's been getting a ton of carries and catches and should be the team's main target this week. With the tight end out and a backup QB, more throws will come his way, and he matches up well against Arizona.

Start Christian McCaffrey — with the 49ers missing key pass-catchers he should touch the ball 20–30+ times and catch plenty of passes, so he’s a safe play. He had a minor calf issue but is listed active; only sit him if he’s officially ruled out before kickoff.

Start Christian McCaffrey if he plays — he usually piles up yards and touchdowns against Seattle and will get a lot of touches. He’s dealing with a calf issue, so check his game-day status; if he can’t go, plug in Brian Robinson Jr. instead.

Yes — take him in the late first or early second round if you want a player who can carry your team when healthy, but remember he's 29 and has a history of leg injuries. Experts disagree, so only pick him if you’re okay with the risk and also grab his backup in case he misses time.