Jacksonville Jaguars

If George Kittle or Jauan Jennings are out or limited, start the Jaguars — they should be able to pressure the 49ers and force turnovers or a low score. If both are healthy, it’s a tougher call, so wait for the final injury news before you lock your lineup.

Play Jacksonville’s defense — their pass rush should give Houston’s shaky offensive line a hard time and likely lead to sacks and turnovers. Stormy weather could cut down total yardage, but this matchup is worth starting them or picking them up if they’re available.

This game looks like a high-scoring shootout, so don't start the Jaguars' defense — they’re more likely to give up points than make game-changing plays. Go with a defense facing a weaker offense that can actually get sacks or force turnovers; experts are split so I'm only about 50% sure.

Don’t take the Jaguars defense early — only pick them in the late rounds as a cheap bench option or for weeks they face bad offenses. They don’t make many big plays, so they probably won’t score well every week even with an easier schedule.