Los Angeles Chargers

Start the Chargers defense — they make a lot of turnovers and they play indoors, which raises the chance for big defensive plays. Just know the Broncos don’t give up many sacks and the game could be a shootout, so double-check injuries and your league’s scoring before locking them in.

Start or pick up the Chargers’ defense — they pressured and sacked the quarterback a lot in Week 1 and the Raiders have been giving up sacks, so the Chargers could force big plays and points. Just check Brock Bowers’ knee before you lock them in, because if he plays he might take away some goal-line chances.

Don’t start the Chargers defense against the Chiefs — Patrick Mahomes and Kansas City throw deep and those games turn into shootouts. Keep them on the bench in tough matchups, but consider them in easier spots like Week 2 at Las Vegas or Week 4 at New York.

Late rounds: grab the Chargers' defense as a cheap gamble. They could have some big weeks because the schedule and group are solid, but an injured offensive line and low roster interest make them shaky, so only pick them after your starters and be ready to replace them if they don’t pay off.