New Orleans Saints

They're up against a tough Bills team, so the Saints probably won't make big defensive plays or score and could give up points instead. Don't play them this week — they look more likely to hurt your team than help.

Start the Saints' defense — the weather is nice and the matchup looks playable, so experts leaning that way have a solid reason. Still, they can be hit-or-miss and Seattle road games are unpredictable, so it’s a reasonable gamble, not a sure thing.

Start New Orleans’ defense — San Francisco might be missing key receivers and their QB is uncertain, which makes interceptions, short fields, and defensive scores more likely. Still, some experts warn the 49ers can be dangerous even when hurt, so check last‑minute injury news and treat this as a medium‑confidence call.

Don't start the Saints defense — they look shaky and the matchup is bad. Arizona's improved pass rush and a shaky rookie quarterback make the game unpredictable, so New Orleans probably won't score many points.